InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lyz1

Summary

InnateDB Protein

IDBP-191768.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lyz1

Protein Name

lysozyme 1

Synonyms

Lyz; Lzp-s;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089800

InnateDB Gene

IDBG-191766 (Lyz1)

Protein Structure

UniProt Annotation

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-postive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram- positive bacteria. {ECO:0000255PROSITE-ProRule:PRU00680, ECO:0000269PubMed:14977423}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed strongly only in small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003796	lysozyme activity

Biological Process

GO:0016998	cell wall macromolecule catabolic process
GO:0019835	cytolysis
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

MGI:96902

InterPro

IPR000974 Glycoside hydrolase, family 22, lysozyme
IPR001916 Glycoside hydrolase, family 22
IPR008258 Lytic transglycosylase-like SLT domain
IPR023346 Lysozyme-like domain

PFAM

PF00062
PF01464
PF13406

PRINTS

PR00137
PR00135

PIRSF

SMART

SM00263

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt