InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Iscu

Summary

InnateDB Protein

IDBP-191862.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Iscu

Protein Name

IscU iron-sulfur cluster scaffold homolog (E. coli)

Synonyms

2310020H20Rik; AA407971; Nifu; Nifun;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026937

InnateDB Gene

IDBG-191860 (Iscu)

Protein Structure

UniProt Annotation

Function

Involved in the assembly or repair of [Fe-S] clusters that are present in iron-sulfur proteins. Binds iron (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0032947	protein complex scaffold
GO:0051536	iron-sulfur cluster binding

Biological Process

GO:0016226

iron-sulfur cluster assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1913633

InterPro

IPR002871 NIF system FeS cluster assembly, NifU, N-terminal
IPR011339 ISC system FeS cluster assembly, IscU scaffold

PFAM

PF01592

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D7P6

PhosphoSite

PhosphoSite-Q9D7P6

TrEMBL

UniProt Splice Variant

Entrez Gene

66383

UniGene

RefSeq

NP_079802

MGI ID

1WFZ

MGI Symbol

Iscu

OMIM

CCDS

CCDS19553

HPRD

IMGT

EMBL

AK009021 AK039834 AK083247 BC028800 BC048409 BC096049

GenPept

AAH28800 AAH48409 AAH96049 BAB26031 BAC30464 BAC38830