Version 5.4
Mus musculus Protein: Selplg
Summary
InnateDB Protein IDBP-191894.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Selplg
Protein Name selectin, platelet (p-selectin) ligand
Synonyms CD162; Psgl-1; Psgl1; Selp1; Selpl;
Species Mus musculus
Ensembl Protein ENSMUSP00000098436
InnateDB Gene IDBG-191890 (Selplg)
Protein Structure
UniProt Annotation
Function A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. {ECO:0000269PubMed:11104809, ECO:0000269PubMed:12370362, ECO:0000269PubMed:17442598}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in blood, bone marrow, brain, adipose tissue, spleen, and thymus. Also expressed in heart, kidney, liver, muscle, ovary, and stomach. {ECO:0000269PubMed:8639776}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0050901 leukocyte tethering or rolling
GO:0050902 leukocyte adhesive activation
GO:0071354 cellular response to interleukin-6
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:106689
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62170
PhosphoSite PhosphoSite-Q62170
TrEMBL Q3TA56
UniProt Splice Variant
Entrez Gene 20345
UniGene Mm.416231
RefSeq NP_033177
MGI ID 2EMT
MGI Symbol Selplg
OMIM
CCDS CCDS51621
HPRD
IMGT
EMBL AC159240 AK172077 CH466529 X91144
GenPept BAE42814 CAA62583 EDL19934

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca