InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sf3b3

Summary

InnateDB Protein

IDBP-192221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sf3b3

Protein Name

splicing factor 3b, subunit 3

Synonyms

1810061H24Rik; 5730409A01Rik; AA409318; D8Ertd633e; mKIAA0017; RSE1; SAP130;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045073

InnateDB Gene

IDBG-192219 (Sf3b3)

Protein Structure

UniProt Annotation

Function

Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 110 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	110 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003676	nucleic acid binding
GO:0005515	protein binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005689	U12-type spliceosomal complex
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:1289341

InterPro

IPR004871 Cleavage/polyadenylation specificity factor, A subunit, C-terminal
IPR017986 WD40-repeat-containing domain

PFAM

PF03178

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q921M3

PhosphoSite

PhosphoSite-Q921M3

TrEMBL

B2RSV4

UniProt Splice Variant

Entrez Gene

101943

UniGene

Mm.399700

RefSeq

NP_598714

MGI ID

MGI Symbol

Sf3b3

OMIM

CCDS

CCDS22665

HPRD

IMGT

EMBL

AK085705 AK088268 AK129035 AK147914 BC011412 BC031197 BC042580 BC139015 BC139016 CH466525

GenPept

AAH11412 AAH31197 AAH42580 AAI39016 AAI39017 BAC39513 BAC40248 BAC97845 BAE28225 EDL11472