InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spsb4

Summary

InnateDB Protein

IDBP-192226.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spsb4

Protein Name

splA/ryanodine receptor domain and SOCS box containing 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057849

InnateDB Gene

IDBG-192224 (Spsb4)

Protein Structure

UniProt Annotation

Function

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0008150	biological_process
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005575	cellular_component
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2183445

InterPro

IPR001496 SOCS protein, C-terminal
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup

PFAM

PF07525
PF00622

PRINTS

PIRSF

SMART

SM00253
SM00969
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R5B6