InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cand1

Summary

InnateDB Protein

IDBP-192258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cand1

Protein Name

cullin associated and neddylation disassociated 1

Synonyms

2310038O07Rik; 6330512O03Rik; AI195005; AI846556; D10Ertd516e; mKIAA0829; Tp120a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020315

InnateDB Gene

IDBG-192256 (Cand1)

Protein Structure

UniProt Annotation

Function

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 573 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	573 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0017025	TBP-class protein binding

Biological Process

GO:0010265	SCF complex assembly
GO:0016567	protein ubiquitination
GO:0030154	cell differentiation
GO:0043086	negative regulation of catalytic activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031461	cullin-RING ubiquitin ligase complex
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome