InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prss12

Summary

InnateDB Protein

IDBP-192281.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prss12

Protein Name

protease, serine, 12 neurotrypsin (motopsin)

Synonyms

Bssp-3; motopsin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029603

InnateDB Gene

IDBG-192279 (Prss12)

Protein Structure

UniProt Annotation

Function

Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Most abundant in cerebral cortex, hippocampus and amygdala.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006887	exocytosis
GO:0006898	receptor-mediated endocytosis
GO:0031638	zymogen activation

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0043083	synaptic cleft
GO:0043195	terminal bouton
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:1100881

InterPro

IPR000001 Kringle
IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold
IPR017448 SRCR-like domain

PFAM

PF00051
PF00530
PF00089

PRINTS

PR00258
PR00722

PIRSF

SMART

SM00130
SM00020
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt