InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mdm4

Summary

InnateDB Protein

IDBP-192395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mdm4

Protein Name

transformed mouse 3T3 cell double minute 4

Synonyms

4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; Mdmx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070411

InnateDB Gene

IDBG-192393 (Mdm4)

Protein Structure

UniProt Annotation

Function

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

In all tissues tested. The short isoform is expressed in a variety of transformed cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0042177	negative regulation of protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0045023	G0 to G1 transition
GO:0050821	protein stabilization
GO:0071157	negative regulation of cell cycle arrest
GO:0071456	cellular response to hypoxia