InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Copb2

Summary

InnateDB Protein

IDBP-192455.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Copb2

Protein Name

coatomer protein complex, subunit beta 2 (beta prime)

Synonyms

AI256832;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035033

InnateDB Gene

IDBG-192453 (Copb2)

Protein Structure

UniProt Annotation

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:17360540}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006891	intra-Golgi vesicle-mediated transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0030117	membrane coat
GO:0030126	COPI vesicle coat

Protein Structure and Domains

PDB ID

MGI:1354962

InterPro

IPR001680 WD40 repeat
IPR006692 Coatomer, WD associated region
IPR016453 Coatomer beta\' subunit (COPB2)
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF04053

PRINTS

PR00320

PIRSF

PIRSF005567

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References