Version 5.4
Homo sapiens Protein: CCL28
Summary
InnateDB Protein IDBP-19272.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL28
Protein Name chemokine (C-C motif) ligand 28
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354416
InnateDB Gene IDBG-19270 (CCL28)
Protein Structure
UniProt Annotation
Function Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007584 response to nutrient
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRJ3
PhosphoSite PhosphoSite-Q9NRJ3
TrEMBL D6RC73
UniProt Splice Variant
Entrez Gene 56477
UniGene Hs.656904
RefSeq NP_683513
HUGO HGNC:17700
OMIM 605240
CCDS CCDS3944
HPRD 05577
IMGT
EMBL AC025457 AF110384 AF220210 AF266504 AK312120 BC062668 BC069532 CH471119 EF064761 HM067700
GenPept AAF87205 AAG16691 AAG43193 AAH62668 AAH69532 ABK41944 ADH95184 BAG35056 EAW56057 EAW56058 EAW56059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca