InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgma

Summary

InnateDB Protein

IDBP-192741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgma

Protein Name

RGM domain family, member A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091870

InnateDB Gene

IDBG-192737 (Rgma)

Protein Structure

UniProt Annotation

Function

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. {ECO:0000269PubMed:14749425, ECO:0000269PubMed:15084667, ECO:0000269PubMed:15975920, ECO:0000269PubMed:17389603, ECO:0000269PubMed:17472960, ECO:0000269PubMed:17953666, ECO:0000269PubMed:18519029}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in gradient in periventricular layers of the developing nervous system. In adult, expressed in scattered cells throughout the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015026	coreceptor activity

Biological Process

GO:0001843	neural tube closure
GO:0001934	positive regulation of protein phosphorylation
GO:0030509	BMP signaling pathway
GO:0030510	regulation of BMP signaling pathway

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome