Version 5.4
Mus musculus Protein: Xpot
Summary
InnateDB Protein IDBP-192957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Xpot
Protein Name exportin, tRNA (nuclear export receptor for tRNAs)
Synonyms 1110004L07Rik; 3110065H13Rik; AI452076; C79645; EXPORTIN-T;
Species Mus musculus
Ensembl Protein ENSMUSP00000043488
InnateDB Gene IDBG-192955 (Xpot)
Protein Structure
UniProt Annotation
Function Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0005488 binding
GO:0008536 Ran GTPase binding
Biological Process
GO:0006409 tRNA export from nucleus
GO:0006886 intracellular protein transport
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1920442
InterPro IPR001494 Importin-beta, N-terminal domain
IPR013598 Exportin-1/Importin-beta-like
IPR016024 Armadillo-type fold
PFAM PF03810
PF08389
PRINTS
PIRSF
SMART SM00913
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CRT8
PhosphoSite PhosphoSite-Q9CRT8
TrEMBL
UniProt Splice Variant
Entrez Gene 73192
UniGene Mm.487930
RefSeq NP_001074525
MGI ID
MGI Symbol Xpot
OMIM
CCDS
HPRD
IMGT
EMBL AC124992 AK014235 BC094337
GenPept AAH94337 BAB29220

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca