InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Larp7

Summary

InnateDB Protein

IDBP-192980.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Larp7

Protein Name

La ribonucleoprotein domain family, member 7

Synonyms

C330027G06Rik; D3Wsu161e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029588

InnateDB Gene

IDBG-192978 (Larp7)

Protein Structure

UniProt Annotation

Function

Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006396	RNA processing
GO:0035562	negative regulation of chromatin binding
GO:0036093	germ cell proliferation
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle