Version 5.4
Mus musculus Protein: Acsbg2
Summary
InnateDB Protein IDBP-193053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acsbg2
Protein Name acyl-CoA synthetase bubblegum family member 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000042352
InnateDB Gene IDBG-193051 (Acsbg2)
Protein Structure
UniProt Annotation
Function Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity Testis- and brainstem-specific. Expressed in pubertal and adult testis. Enriched in germ cells and Sertoli cells while present at a lower level in Leydig cells. Present in testicular Sertoli cells and large motoneurons in the medulla oblongata and cervical spinal cord (at protein level). {ECO:0000269PubMed:16371355, ECO:0000269PubMed:16762313}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0047617 acyl-CoA hydrolase activity
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0008152 metabolic process
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:3587728
InterPro IPR000873 AMP-dependent synthetase/ligase
PFAM PF00501
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2XU92
PhosphoSite PhosphoSite-Q2XU92
TrEMBL
UniProt Splice Variant
Entrez Gene 328845
UniGene Mm.179421
RefSeq NP_001034203
MGI ID
MGI Symbol Acsbg2
OMIM
CCDS CCDS28916
HPRD
IMGT
EMBL DQ250679
GenPept ABB54488

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca