InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mecr

Summary

InnateDB Protein

IDBP-193278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mecr

Protein Name

mitochondrial trans-2-enoyl-CoA reductase

Synonyms

AI195831; Nrbf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030742

InnateDB Gene

IDBG-193276 (Mecr)

Protein Structure

UniProt Annotation

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2- decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0016922	ligand-dependent nuclear receptor binding
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1349441

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DCS3