Version 5.4
Mus musculus Protein: Agbl1
Summary
InnateDB Protein IDBP-193284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agbl1
Protein Name ATP/GTP binding protein-like 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000026854
InnateDB Gene IDBG-193282 (Agbl1)
Protein Structure
UniProt Annotation
Function Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000269PubMed:21074048}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at low level. Expressed in eye, muscle, pituitary, testis and to a lower extent in brain. {ECO:0000269PubMed:17244818, ECO:0000269PubMed:21074048}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004181 metallocarboxypeptidase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015631 tubulin binding
Biological Process
GO:0006508 proteolysis
GO:0035609 C-terminal protein deglutamylation
GO:0035610 protein side chain deglutamylation
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:3646469
InterPro IPR000834 Peptidase M14, carboxypeptidase A
PFAM PF00246
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q09M05
PhosphoSite PhosphoSite-Q09M05
TrEMBL
UniProt Splice Variant
Entrez Gene 244071
UniGene Mm.322829
RefSeq
MGI ID
MGI Symbol Agbl1
OMIM
CCDS
HPRD
IMGT
EMBL AC115830 AC121812 AC121971 AC123792 AC165265 AK052433 DQ867033 FN429927
GenPept ABI51952 BAC34986 CAZ69802

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca