Version 5.4
Mus musculus Protein: Ldlrad3
Summary
InnateDB Protein IDBP-193357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ldlrad3
Protein Name low density lipoprotein receptor class A domain containing 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000054134
InnateDB Gene IDBG-193355 (Ldlrad3)
Protein Structure
UniProt Annotation
Function May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. {ECO:0000269PubMed:21795536}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:21795536}; Single-pass type I membrane protein {ECO:0000269PubMed:21795536}.
Disease Associations
Tissue Specificity Expressed in the cerebral cortex and hippocampus. {ECO:0000269PubMed:21795536}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0070613 regulation of protein processing
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID MGI:2138856
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
PFAM PF00057
PRINTS PR00261
PIRSF
SMART SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2AR95
PhosphoSite PhosphoSite-
TrEMBL B7ZND2
UniProt Splice Variant
Entrez Gene 241576
UniGene Mm.489740
RefSeq NP_849217
MGI ID
MGI Symbol Ldlrad3
OMIM
CCDS CCDS38187
HPRD
IMGT
EMBL AK029683 AK032208 AL845300 BC138177 BC138178 BC145174 BX322585 BX571894 CH466519
GenPept AAI38178 AAI38179 AAI45175 BAC26562 BAC27759 CAM17408 CAM17409 CAM19751 CAM19752 CAM23213 CAM23214 EDL27664

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca