InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyb5r1

Summary

InnateDB Protein

IDBP-193698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyb5r1

Protein Name

cytochrome b5 reductase 1

Synonyms

1500005G05Rik; B5R.1; C80155; Nqo3a2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027726

InnateDB Gene

IDBG-193696 (Cyb5r1)

Protein Structure

UniProt Annotation

Function

NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0016491	oxidoreductase activity

Biological Process

GO:0016126	sterol biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1919267

InterPro

IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR001834 NADH:cytochrome b5 reductase (CBR)
IPR008333 Oxidoreductase, FAD-binding domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00175
PF00970

PRINTS

PR00371
PR00406

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DB73