InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmem231

Summary

InnateDB Protein

IDBP-193724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmem231

Protein Name

transmembrane protein 231

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034429

InnateDB Gene

IDBG-193722 (Tmem231)

Protein Structure

UniProt Annotation

Function

Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. {ECO:0000269PubMed:22179047}.

Subcellular Localization

Cell projection, cilium membrane {ECO:0000269PubMed:22179047}; Multi-pass membrane protein {ECO:0000269PubMed:22179047}. Note=Localizes to the transition zone of primary cilia; SEPT2 is required for localization to the transition zone.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001944	vasculature development
GO:0007224	smoothened signaling pathway
GO:0032880	regulation of protein localization
GO:0042384	cilium assembly
GO:0042733	embryonic digit morphogenesis
GO:0043010	camera-type eye development
GO:0060563	neuroepithelial cell differentiation