InnateDB Protein
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IDBP-193730.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Triap1
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Protein Name
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TP53 regulated inhibitor of apoptosis 1
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Synonyms
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1810015M01Rik; AU020874; AU043831; P53csv; Wf-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000031508
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InnateDB Gene
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IDBG-193728 (Triap1)
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Protein Structure
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Function |
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probbaly functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000250}. Mitochondrion intermembrane space.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0002039
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p53 binding
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GO:0005515
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protein binding
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GO:0043027
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cysteine-type endopeptidase inhibitor activity involved in apoptotic process
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GO:1990050
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phosphatidic acid transporter activity
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Biological Process |
GO:0015914
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phospholipid transport
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GO:0030330
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DNA damage response, signal transduction by p53 class mediator
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GO:0034644
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cellular response to UV
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GO:0043066
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negative regulation of apoptotic process
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GO:0043154
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negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0090201
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negative regulation of release of cytochrome c from mitochondria
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GO:0097035
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regulation of membrane lipid distribution
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GO:1902166
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negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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GO:2001140
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positive regulation of phospholipid transport
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Cellular Component |
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PDB ID |
MGI:1916326
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InterPro |
IPR007918
Mitochondrial distribution/morphology family 35/apoptosis
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PFAM |
PF05254
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D8Z2
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PhosphoSite |
PhosphoSite-Q9D8Z2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
69076
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UniGene |
Mm.27951
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RefSeq |
NP_081209
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MGI ID |
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MGI Symbol |
Triap1
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OMIM |
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CCDS |
CCDS39228
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HPRD |
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IMGT |
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EMBL |
AK007514
BC030325
U61156
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GenPept |
AAH30325
AAR00569
BAB25082
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