InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL11B

Summary

InnateDB Protein

IDBP-19377.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL11B

Protein Name

B-cell CLL/lymphoma 11B (zinc finger protein)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000349723

InnateDB Gene

IDBG-19375 (BCL11B)

Protein Structure

UniProt Annotation

Function

Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	34 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0003334	keratinocyte development
GO:0003382	epithelial cell morphogenesis
GO:0006351	transcription, DNA-templated
GO:0007409	axonogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0010837	regulation of keratinocyte proliferation
GO:0019216	regulation of lipid metabolic process
GO:0021773	striatal medium spiny neuron differentiation
GO:0021953	central nervous system neuron differentiation
GO:0031077	post-embryonic camera-type eye development
GO:0033077	T cell differentiation in thymus
GO:0033153	T cell receptor V(D)J recombination
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043066	negative regulation of apoptotic process
GO:0043368	positive T cell selection
GO:0043588	skin development
GO:0045664	regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046632	alpha-beta T cell differentiation
GO:0048538	thymus development
GO:0071678	olfactory bulb axon guidance