InnateDB Protein
|
IDBP-19379.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
BCL11B
|
Protein Name
|
B-cell CLL/lymphoma 11B (zinc finger protein)
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000280435
|
InnateDB Gene
|
IDBG-19375 (BCL11B)
|
Protein Structure
|
|
Function |
Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000305}.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
36
[view]
|
Protein-Protein |
34
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
1
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006351
|
transcription, DNA-templated
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
|
PFAM |
PF00096
|
PRINTS |
|
PIRSF |
|
SMART |
SM00355
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9C0K0
|
PhosphoSite |
PhosphoSite-Q9C0K0
|
TrEMBL |
L8B567
|
UniProt Splice Variant |
|
Entrez Gene |
64919
|
UniGene |
Hs.709690
|
RefSeq |
NP_075049
|
HUGO |
HGNC:13222
|
OMIM |
606558
|
CCDS |
CCDS9949
|
HPRD |
05950
|
IMGT |
|
EMBL |
AB043584
AB057669
AJ404614
CH471061
|
GenPept |
BAB32731
BAM78284
CAC17726
EAW81662
|
|
|