InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Os9

Summary

InnateDB Protein

IDBP-194189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Os9

Protein Name

amplified in osteosarcoma

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079770

InnateDB Gene

IDBG-194187 (Os9)

Protein Structure

UniProt Annotation

Function

Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0002020	protease binding

Biological Process

GO:0006605	protein targeting
GO:0006621	protein retention in ER lumen
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0034976	response to endoplasmic reticulum stress
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process