InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lef1

Summary

InnateDB Protein

IDBP-194294.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lef1

Protein Name

lymphoid enhancer binding factor 1

Synonyms

3000002B05; AI451430; Lef-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029611

InnateDB Gene

IDBG-194292 (Lef1)

Protein Structure

UniProt Annotation

Function

Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. {ECO:0000250, ECO:0000269PubMed:11445543}.

Subcellular Localization

Nucleus. Note=Found in nuclear bodies upon PIASG binding.

Disease Associations

Tissue Specificity

Lymphocytes. Found in distinct epithelial cell compartments of the skin and is abundant in the hair-producing progenitors of the follicle. {ECO:0000269PubMed:10498690}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	31 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0030284	estrogen receptor activity
GO:0030331	estrogen receptor binding
GO:0035326	enhancer binding
GO:0042393	histone binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0045295	gamma-catenin binding
GO:0070016	armadillo repeat domain binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001569	patterning of blood vessels
GO:0001649	osteoblast differentiation
GO:0001755	neural crest cell migration
GO:0001756	somitogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0001944	vasculature development
GO:0002040	sprouting angiogenesis
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016055	Wnt signaling pathway
GO:0021542	dentate gyrus development
GO:0021766	hippocampus development
GO:0021854	hypothalamus development
GO:0021861	forebrain radial glial cell differentiation
GO:0021873	forebrain neuroblast division
GO:0021879	forebrain neuron differentiation
GO:0021943	formation of radial glial scaffolds
GO:0022407	regulation of cell-cell adhesion
GO:0022408	negative regulation of cell-cell adhesion
GO:0022409	positive regulation of cell-cell adhesion
GO:0030111	regulation of Wnt signaling pathway
GO:0030223	neutrophil differentiation
GO:0030307	positive regulation of cell growth
GO:0030326	embryonic limb morphogenesis
GO:0030335	positive regulation of cell migration
GO:0030509	BMP signaling pathway
GO:0030854	positive regulation of granulocyte differentiation
GO:0030879	mammary gland development
GO:0032696	negative regulation of interleukin-13 production
GO:0032713	negative regulation of interleukin-4 production
GO:0032714	negative regulation of interleukin-5 production
GO:0033153	T cell receptor V(D)J recombination
GO:0042100	B cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0043401	steroid hormone mediated signaling pathway
GO:0043586	tongue development
GO:0043923	positive regulation by host of viral transcription
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045063	T-helper 1 cell differentiation
GO:0045843	negative regulation of striated muscle tissue development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046632	alpha-beta T cell differentiation
GO:0048069	eye pigmentation
GO:0048341	paraxial mesoderm formation
GO:0048468	cell development
GO:0048747	muscle fiber development
GO:0050909	sensory perception of taste
GO:0060021	palate development
GO:0060033	anatomical structure regression
GO:0060070	canonical Wnt signaling pathway
GO:0060325	face morphogenesis
GO:0060326	cell chemotaxis
GO:0060561	apoptotic process involved in morphogenesis
GO:0060710	chorio-allantoic fusion
GO:0061153	trachea gland development
GO:0071345	cellular response to cytokine stimulus
GO:0071353	cellular response to interleukin-4
GO:0071864	positive regulation of cell proliferation in bone marrow
GO:0071866	negative regulation of apoptotic process in bone marrow
GO:0071895	odontoblast differentiation
GO:0071899	negative regulation of estrogen receptor binding
GO:0090068	positive regulation of cell cycle process
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1902262	apoptotic process involved in patterning of blood vessels