InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Papss1

Summary

InnateDB Protein

IDBP-194466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Papss1

Protein Name

3'-phosphoadenosine 5'-phosphosulfate synthase 1

Synonyms

AI325286; Asapk; SK1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029666

InnateDB Gene

IDBG-194464 (Papss1)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in the neonatal brain and in cartilage.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004020	adenylylsulfate kinase activity
GO:0004781	sulfate adenylyltransferase (ATP) activity
GO:0005524	ATP binding
GO:0016779	nucleotidyltransferase activity

Biological Process

GO:0000103	sulfate assimilation
GO:0016310	phosphorylation
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

Cellular Component

GO:0009336

sulfate adenylyltransferase complex (ATP)

Protein Structure and Domains

PDB ID

MGI:1330587

InterPro

IPR002650 Sulphate adenylyltransferase
IPR002891 Adenylylsulphate kinase
IPR015947 PUA-like domain
IPR024951 Sulphate adenylyltransferase catalytic domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01583
PF01747

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q60967

PhosphoSite