Version 5.4
Mus musculus Protein: Hebp1
Summary
InnateDB Protein IDBP-194494.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hebp1
Protein Name heme binding protein 1
Synonyms Hebp;
Species Mus musculus
Ensembl Protein ENSMUSP00000042232
InnateDB Gene IDBG-194492 (Hebp1)
Protein Structure
UniProt Annotation
Function May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N- methylprotoporphyrin with similar affinities. {ECO:0000269PubMed:12413491, ECO:0000269PubMed:16905545}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12413491, ECO:0000269PubMed:9813049}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Extremely abundant in liver. {ECO:0000269PubMed:9813049}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0020037 heme binding
Biological Process
GO:0042168 heme metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1333880
InterPro IPR006917 SOUL haem-binding protein
IPR011256 Regulatory factor, effector binding domain
PFAM PF04832
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R257
PhosphoSite PhosphoSite-Q9R257
TrEMBL
UniProt Splice Variant
Entrez Gene 15199
UniGene
RefSeq NP_038574
MGI ID 4A1M
MGI Symbol Hebp1
OMIM
CCDS CCDS20645
HPRD
IMGT
EMBL AB013095 AC131718 AF117613 BC012654 CT010262
GenPept AAD32096 AAH12654 BAA33770 CAJ18470

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca