InnateDB Protein
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IDBP-194540.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dkk2
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Protein Name
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dickkopf homolog 2 (Xenopus laevis)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000029665
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InnateDB Gene
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IDBG-194538 (Dkk2)
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Protein Structure
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Function |
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269PubMed:18524778}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0008270
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zinc ion binding
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0007275
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multicellular organismal development
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GO:0016055
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Wnt signaling pathway
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GO:0030178
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negative regulation of Wnt signaling pathway
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GO:0090090
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negative regulation of canonical Wnt signaling pathway
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GO:0090263
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positive regulation of canonical Wnt signaling pathway
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Cellular Component |
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PDB ID |
MGI:1890663
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InterPro |
IPR001138
Zn(2)-C6 fungal-type DNA-binding domain
IPR006796
Dickkopf, N-terminal cysteine-rich
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PFAM |
PF00172
PF04706
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PRINTS |
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PIRSF |
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SMART |
SM00066
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QYZ8
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56811
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UniGene |
Mm.103593
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RefSeq |
NP_064661
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MGI ID |
2JTK
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MGI Symbol |
Dkk2
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OMIM |
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CCDS |
CCDS17844
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HPRD |
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IMGT |
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EMBL |
AC127260
AJ243963
AK028225
AK031749
BC096448
CH466532
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GenPept |
AAH96448
BAC25824
BAC27536
CAB60110
EDL12195
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