Version 5.4
Homo sapiens Protein: SETD3
Summary
InnateDB Protein IDBP-19476.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SETD3
Protein Name SET domain containing 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000327910
InnateDB Gene IDBG-19470 (SETD3)
Protein Structure
UniProt Annotation
Function Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0046975 histone methyltransferase activity (H3-K36 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0010452 histone H3-K36 methylation
GO:0018023 peptidyl-lysine trimethylation
GO:0018026 peptidyl-lysine monomethylation
GO:0018027 peptidyl-lysine dimethylation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001214 SET domain
PFAM PF00856
PRINTS
PIRSF
SMART SM00317
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86TU7
PhosphoSite PhosphoSite-Q86TU7
TrEMBL
UniProt Splice Variant
Entrez Gene 84193
UniGene
RefSeq NP_954574
HUGO HGNC:20493
OMIM 615671
CCDS CCDS9952
HPRD 08664
IMGT
EMBL AK026680 AK302882 AL110504 AL132819 AL359581 BC009054 BC120967 BC120968 BC127624 BC127625 BC142995 BC148251 BX161441 BX161471 CH471061
GenPept AAH09054 AAI20968 AAI20969 AAI27625 AAI27626 AAI42996 AAI48252 BAB15525 BAG64060 CAD61911 CAD61927 CAH56365 EAW81664 EAW81665

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca