Version 5.4
Mus musculus Protein: Ints12
Summary
InnateDB Protein IDBP-194891.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ints12
Protein Name integrator complex subunit 12
Synonyms 1110020M19Rik; 2810027J24Rik; 4930529N21Rik; A230056J18Rik; AI666778; Phf22;
Species Mus musculus
Ensembl Protein ENSMUSP00000029650
InnateDB Gene IDBG-194889 (Ints12)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID MGI:1919043
InterPro IPR001965 Zinc finger, PHD-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
PFAM PF00628
PRINTS
PIRSF
SMART SM00249
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D168
PhosphoSite PhosphoSite-Q9D168
TrEMBL
UniProt Splice Variant
Entrez Gene 71793
UniGene Mm.480982
RefSeq NP_082203
MGI ID 1WEV
MGI Symbol Ints12
OMIM
CCDS CCDS17848
HPRD
IMGT
EMBL AK003874 AK155162 BC010657 BC023801 BC046996
GenPept AAH10657 AAH23801 AAH46996 BAB23052 BAE33085

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca