InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hsd17b2

Summary

InnateDB Protein

IDBP-195211.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsd17b2

Protein Name

hydroxysteroid (17-beta) dehydrogenase 2

Synonyms

AI194836; AI194967; AI255511;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034304

InnateDB Gene

IDBG-195209 (Hsd17b2)

Protein Structure

UniProt Annotation

Function

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004303	estradiol 17-beta-dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0047035	testosterone dehydrogenase (NAD+) activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0006694	steroid biosynthetic process
GO:0008152	metabolic process
GO:0032526	response to retinoic acid
GO:0055114	oxidation-reduction process

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1096386

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013952 Protein of unknown function DUF1776, fungi
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF08643
PF08659

PRINTS

PR00080
PR00081

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt