InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shmt2

Summary

InnateDB Protein

IDBP-195292.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Shmt2

Protein Name

serine hydroxymethyltransferase 2 (mitochondrial)

Synonyms

2700043D08Rik; AA408223; AA986903;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026470

InnateDB Gene

IDBG-195290 (Shmt2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004372	glycine hydroxymethyltransferase activity
GO:0008732	L-allo-threonine aldolase activity
GO:0016597	amino acid binding
GO:0030170	pyridoxal phosphate binding
GO:0042802	identical protein binding

Biological Process

GO:0006544	glycine metabolic process
GO:0006545	glycine biosynthetic process
GO:0006563	L-serine metabolic process
GO:0006564	L-serine biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0019264	glycine biosynthetic process from serine
GO:0035999	tetrahydrofolate interconversion
GO:0051289	protein homotetramerization

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005759	mitochondrial matrix
GO:0015630	microtubule cytoskeleton
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome