InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Camsap2

Summary

InnateDB Protein

IDBP-195514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Camsap2

Protein Name

calmodulin regulated spectrin-associated protein family, member 2

Synonyms

1600013L13Rik; 4930541M15Rik; Camsap1l1; mKIAA1078;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041920

InnateDB Gene

IDBG-195512 (Camsap2)

Protein Structure

UniProt Annotation

Function

Microtubule minus-end binding protein that may regulate the organization of non-centrosomal microtubules. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes. {ECO:0000269PubMed:23169647}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the minus-end of microtubules and also detected at the centrosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0051011	microtubule minus-end binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0033043	regulation of organelle organization

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0036449	microtubule minus-end

Protein Structure and Domains

PDB ID

MGI:1922434

InterPro

IPR001715 Calponin homology domain
IPR011033 PRC-barrel-like
IPR014797 CKK domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM

PF00307
PF08683
PF11971

PRINTS

PIRSF

SMART

SM00033
SM01051

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8C1B1