Mus musculus Protein: Cisd2
Summary
InnateDB Protein IDBP-195531.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cisd2
Protein Name CDGSH iron sulfur domain 2
Synonyms 1500009M05Rik; 1500026J14Rik; 1500031D15Rik; AI848398; B630006A20Rik; Miner1; Noxp70; Zcd2;
Species Mus musculus
Ensembl Protein ENSMUSP00000029815
InnateDB Gene IDBG-195529 (Cisd2)
Protein Structure
UniProt Annotation
Function Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:19451219}; Single-pass membrane protein {ECO:0000269PubMed:19451219}. Mitochondrion outer membrane {ECO:0000269PubMed:19451219}; Single-pass membrane protein {ECO:0000269PubMed:19451219}. Note=According to PubMed:19451219, it mainly localizes to the mitochondrion outer membrane and localizes only at low level to the endoplasmic reticulum. However, inverse results are observed in human cells.
Disease Associations
Tissue Specificity Brain. {ECO:0000269PubMed:17029606}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0000422 mitochondrion degradation
GO:0010259 multicellular organismal aging
GO:0010506 regulation of autophagy
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1914256
InterPro IPR006622 Iron sulphur-containing domain, CDGSH-type, subfamily
IPR018967 Iron sulphur-containing domain, CDGSH-type
IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal
PFAM PF09360
PF10660
PRINTS
PIRSF
SMART SM00704
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQB5
PhosphoSite PhosphoSite-Q9CQB5
TrEMBL
UniProt Splice Variant
Entrez Gene 67006
UniGene
RefSeq NP_080178
MGI ID
MGI Symbol Cisd2
OMIM
CCDS CCDS17856
HPRD
IMGT
EMBL AK003486 AK004257 AK005184 AM162549 BC058279
GenPept AAH58279 BAB22814 BAB23237 BAB23868 CAJ44265