InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cisd2

Summary

InnateDB Protein

IDBP-195531.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cisd2

Protein Name

CDGSH iron sulfur domain 2

Synonyms

1500009M05Rik; 1500026J14Rik; 1500031D15Rik; AI848398; B630006A20Rik; Miner1; Noxp70; Zcd2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029815

InnateDB Gene

IDBG-195529 (Cisd2)

Protein Structure

UniProt Annotation

Function

Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:19451219}; Single-pass membrane protein {ECO:0000269PubMed:19451219}. Mitochondrion outer membrane {ECO:0000269PubMed:19451219}; Single-pass membrane protein {ECO:0000269PubMed:19451219}. Note=According to PubMed:19451219, it mainly localizes to the mitochondrion outer membrane and localizes only at low level to the endoplasmic reticulum. However, inverse results are observed in human cells.

Disease Associations

Tissue Specificity

Brain. {ECO:0000269PubMed:17029606}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0000422	mitochondrion degradation
GO:0010259	multicellular organismal aging
GO:0010506	regulation of autophagy

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1914256

InterPro

IPR006622 Iron sulphur-containing domain, CDGSH-type, subfamily
IPR018967 Iron sulphur-containing domain, CDGSH-type
IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal

PFAM

PF09360
PF10660

PRINTS

PIRSF

SMART

SM00704

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CQB5