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InnateDB Protein
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IDBP-195634.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Taf1c
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Protein Name
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TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C
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Synonyms
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mTAFI95; Tafi95;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000090789
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InnateDB Gene
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IDBG-195632 (Taf1c)
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Protein Structure
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| Function |
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3 (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Nucleus {ECO:0000269PubMed:9451438}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
8
[view]
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| Protein-Protein |
8
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
15 [view]
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Molecular Function |
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| Biological Process |
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006360
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transcription from RNA polymerase I promoter
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| Cellular Component |
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GO:0000120
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RNA polymerase I transcription factor complex
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| PDB ID |
MGI:109576
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| InterPro |
IPR017986
WD40-repeat-containing domain
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q6PDZ2
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| PhosphoSite |
PhosphoSite-Q6PDZ2
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
21341
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| UniGene |
Mm.41977
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| RefSeq |
NP_067416
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| MGI ID |
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| MGI Symbol |
Taf1c
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| OMIM |
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| CCDS |
CCDS40493
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| HPRD |
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| IMGT |
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| EMBL |
AK087534
AK154846
BC058383
Y09974
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| GenPept |
AAH58383
BAC39916
BAE32872
CAA71093
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Version 5.4