InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp3ca

Summary

InnateDB Protein

IDBP-195769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp3ca

Protein Name

protein phosphatase 3, catalytic subunit, alpha isoform

Synonyms

2900074D19Rik; Caln; Calna; CN; CnA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071040

InnateDB Gene

IDBG-195763 (Ppp3ca)

Protein Structure

UniProt Annotation

Function

Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L and HSPB1 (By similarity). Dephosphorylates SSH1. {ECO:0000250, ECO:0000269PubMed:1328240}.

Subcellular Localization

Cell membrane. Cell membrane, sarcolemma. Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008144	drug binding
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001975	response to amphetamine
GO:0006470	protein dephosphorylation
GO:0006606	protein import into nucleus
GO:0006816	calcium ion transport
GO:0014883	transition between fast and slow fiber
GO:0016311	dephosphorylation
GO:0019722	calcium-mediated signaling
GO:0033173	calcineurin-NFAT signaling cascade
GO:0033555	multicellular organismal response to stress
GO:0035690	cellular response to drug
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046676	negative regulation of insulin secretion
GO:0048741	skeletal muscle fiber development
GO:0050804	regulation of synaptic transmission
GO:0051592	response to calcium ion
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005955	calcineurin complex
GO:0030018	Z disc
GO:0042383	sarcolemma

Protein Structure and Domains

PDB ID

MGI:107164

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt