InnateDB Protein
|
IDBP-195812.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Tpcn1
|
Protein Name
|
two pore channel 1
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000042188
|
InnateDB Gene
|
IDBG-195810 (Tpcn1)
|
Protein Structure
|
|
Function |
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. {ECO:0000250}.
|
Subcellular Localization |
Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2182472
|
InterPro |
IPR005821
Ion transport domain
|
PFAM |
PF00520
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9EQJ0
|
PhosphoSite |
PhosphoSite-Q9EQJ0
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
252972
|
UniGene |
Mm.114054
|
RefSeq |
NP_665852
|
MGI ID |
|
MGI Symbol |
Tpcn1
|
OMIM |
|
CCDS |
CCDS39239
|
HPRD |
|
IMGT |
|
EMBL |
AF217002
AK077411
AK129303
AK148129
BC058951
|
GenPept |
AAG44100
AAH58951
BAC98113
BAE28363
BAE43360
|
|
|