Version 5.4
Mus musculus Protein: Catsper4
Summary
InnateDB Protein IDBP-195945.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Catsper4
Protein Name cation channel, sperm associated 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000051694
InnateDB Gene IDBG-195943 (Catsper4)
Protein Structure
UniProt Annotation
Function Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone. {ECO:0000269PubMed:17227845, ECO:0000269PubMed:17344468}.
Subcellular Localization Cell projection, cilium, flagellum membrane {ECO:0000269PubMed:16107607, ECO:0000269PubMed:17227845}; Multi- pass membrane protein {ECO:0000269PubMed:16107607, ECO:0000269PubMed:17227845}. Note=Specifically located in the principal piece of sperm tail.
Disease Associations
Tissue Specificity Testis-specific. {ECO:0000269PubMed:16107607, ECO:0000269PubMed:17227845}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005227 calcium activated cation channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0007275 multicellular organismal development
GO:0030317 sperm motility
GO:0034765 regulation of ion transmembrane transport
GO:0048240 sperm capacitation
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0001669 acrosomal vesicle
GO:0016020 membrane
GO:0036128 CatSper complex
GO:0097228 sperm principal piece
Protein Structure and Domains
PDB ID MGI:3043288
InterPro IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR016185 Pre-ATP-grasp domain
PFAM PF00520
PF08016
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BVN3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 329954
UniGene Mm.79072
RefSeq NP_808534
MGI ID
MGI Symbol Catsper4
OMIM
CCDS CCDS18766
HPRD
IMGT
EMBL AK077145 AL627314 BC108974 BC108975
GenPept AAI08975 AAI08976 BAC36641 CAM21940 CAM21941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca