InnateDB Protein
|
IDBP-196126.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Aebp2
|
Protein Name
|
AE binding protein 2
|
Synonyms
|
AU023766; B230313N05Rik;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000084896
|
InnateDB Gene
|
IDBG-196120 (Aebp2)
|
Protein Structure
|
|
Function |
May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3 (By similarity). DNA-binding transcriptional repressor. {ECO:0000250, ECO:0000269PubMed:10329662}.
|
Subcellular Localization |
Nucleus {ECO:0000305}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in brain, brown adipose tissue, white adipose tissue, heart, kidney, lung, skeletal muscle, small intestine and spleen. Expressed at low levels in liver. {ECO:0000269PubMed:10329662}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
|
Protein-Protein |
8
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
11 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000978
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding
|
GO:0001078
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
|
GO:0003676
|
nucleic acid binding
|
GO:0003677
|
DNA binding
|
GO:0003714
|
transcription corepressor activity
|
GO:0046872
|
metal ion binding
|
|
Biological Process |
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter
|
GO:0006351
|
transcription, DNA-templated
|
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0016568
|
chromatin modification
|
|
Cellular Component |
|
PDB ID |
MGI:1338038
|
InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
|
PFAM |
PF00096
|
PRINTS |
|
PIRSF |
|
SMART |
SM00355
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Z248
|
PhosphoSite |
PhosphoSite-Q9Z248
|
TrEMBL |
Z4YJG5
|
UniProt Splice Variant |
|
Entrez Gene |
11569
|
UniGene |
Mm.479349
|
RefSeq |
NP_001005605
|
MGI ID |
|
MGI Symbol |
Aebp2
|
OMIM |
|
CCDS |
CCDS20673
|
HPRD |
|
IMGT |
|
EMBL |
AC133098
AF090326
AK029011
AK045838
AK045987
AK155272
BC031376
BC057681
|
GenPept |
AAD02854
AAH31376
AAH57681
BAC26241
BAC32508
BAC32562
BAE33156
|
|
|