Mus musculus Protein: Oas2
Summary
InnateDB Protein IDBP-196259.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Oas2
Protein Name 2'-5' oligoadenylate synthetase 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000060082
InnateDB Gene IDBG-196257 (Oas2)
Protein Structure
UniProt Annotation
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269PubMed:12396720}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. {ECO:0000250}.
Disease Associations
Tissue Specificity Uterus. {ECO:0000269PubMed:12396720}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001730 2'-5'-oligoadenylate synthetase activity
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006401 RNA catabolic process
GO:0006486 protein glycosylation
GO:0006955 immune response
GO:0009615 response to virus
GO:0018377 protein myristoylation
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2180852
InterPro IPR002934 Nucleotidyl transferase domain
IPR006116 2-5-oligoadenylate synthetase, N-terminal
IPR018952 2\'-5\'-oligoadenylate synthetase 1, domain 2/C-terminal
PFAM PF01909
PF10421
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E9Q9A9
PhosphoSite PhosphoSite-E9Q9A9
TrEMBL
UniProt Splice Variant
Entrez Gene 246728
UniGene Mm.260926
RefSeq NP_660262
MGI ID
MGI Symbol Oas2
OMIM
CCDS CCDS19625
HPRD
IMGT
EMBL AB067535 AC115937 AF418010 CH466529
GenPept AAM54499 BAB84135 EDL19753