Mus musculus Protein: Oas2 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Protein | IDBP-196261.7 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | Oas2 | ||||||||||||||||
Protein Name | 2'-5' oligoadenylate synthetase 2 | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Mus musculus | ||||||||||||||||
Ensembl Protein | ENSMUSP00000080209 | ||||||||||||||||
InnateDB Gene | IDBG-196257 (Oas2) | ||||||||||||||||
Protein Structure | |||||||||||||||||
UniProt Annotation | |||||||||||||||||
Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269PubMed:12396720}. | ||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. {ECO:0000250}. | ||||||||||||||||
Disease Associations | |||||||||||||||||
Tissue Specificity | Uterus. {ECO:0000269PubMed:12396720}. | ||||||||||||||||
Comments | |||||||||||||||||
Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||
PDB ID | MGI:2180852 | ||||||||||||||||
InterPro |
IPR002934
Nucleotidyl transferase domain IPR006116 2-5-oligoadenylate synthetase, N-terminal IPR018952 2\'-5\'-oligoadenylate synthetase 1, domain 2/C-terminal |
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PFAM |
PF01909
PF10421 |
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PRINTS | |||||||||||||||||
PIRSF | |||||||||||||||||
SMART | |||||||||||||||||
TIGRFAMs | |||||||||||||||||
Post-translational Modifications | |||||||||||||||||
Modification | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | E9Q9A9 | ||||||||||||||||
PhosphoSite | PhosphoSite-E9Q9A9 | ||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 246728 | ||||||||||||||||
UniGene | Mm.260926 | ||||||||||||||||
RefSeq | XP_006530387 | ||||||||||||||||
MGI ID | |||||||||||||||||
MGI Symbol | Oas2 | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | AB067535 AC115937 AF418010 CH466529 | ||||||||||||||||
GenPept | AAM54499 BAB84135 EDL19753 | ||||||||||||||||