Version 5.4
Mus musculus Protein: Lpcat4
Summary
InnateDB Protein IDBP-196378.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lpcat4
Protein Name lysophosphatidylcholine acyltransferase 4
Synonyms Agpat7; AI505034; Aytl3; LPEAT2;
Species Mus musculus
Ensembl Protein ENSMUSP00000028554
InnateDB Gene IDBG-196376 (Lpcat4)
Protein Structure
UniProt Annotation
Function Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity). Converts lysophosphatidylcholine to phosphatidycholine. {ECO:0000250, ECO:0000269PubMed:18156367}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with much higher level in brain. Expressed in erythroleukemic cells but not in reticulocytes. {ECO:0000269PubMed:18156367, ECO:0000269PubMed:18458083}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016746 transferase activity, transferring acyl groups
GO:0047166 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity
GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity
GO:0071617 lysophospholipid acyltransferase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0008152 metabolic process
GO:0008654 phospholipid biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2138993
InterPro IPR002123 Phospholipid/glycerol acyltransferase
PFAM PF01553
PRINTS
PIRSF
SMART SM00563
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NVG1
PhosphoSite PhosphoSite-Q6NVG1
TrEMBL
UniProt Splice Variant
Entrez Gene 99010
UniGene Mm.33438
RefSeq NP_997089
MGI ID
MGI Symbol Lpcat4
OMIM
CCDS CCDS16548
HPRD
IMGT
EMBL BC068131 BC080829
GenPept AAH68131 AAH80829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca