InnateDB Protein
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IDBP-196406.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Naca
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Protein Name
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nascent polypeptide-associated complex alpha polypeptide
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Synonyms
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AL022831; AL024382; Gm1878; mKIAA0363; skNAC;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000073532
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InnateDB Gene
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IDBG-196404 (Naca)
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Protein Structure
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Function |
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). Isoform 1 and isoform 2 appear to bind DNA and play roles in transcription. Isoform 1 may function as a specific coactivator for JUN, acting to stabilize the interaction of JUN homodimers with promoter elements. {ECO:0000250, ECO:0000269PubMed:15299025, ECO:0000269PubMed:15831452, ECO:0000269PubMed:8698236, ECO:0000269PubMed:9488445, ECO:0000269PubMed:9488446}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 appears to be ubiquitously expressed. {ECO:0000269PubMed:10224091, ECO:0000269PubMed:8698236, ECO:0000269PubMed:9877153}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
24 [view]
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Molecular Function |
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Biological Process |
GO:0003231
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cardiac ventricle development
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GO:0006351
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transcription, DNA-templated
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GO:0010664
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negative regulation of striated muscle cell apoptotic process
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GO:0015031
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protein transport
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GO:0043403
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skeletal muscle tissue regeneration
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GO:0048633
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positive regulation of skeletal muscle tissue growth
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GO:0048742
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regulation of skeletal muscle fiber development
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GO:0051451
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myoblast migration
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GO:0061384
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heart trabecula morphogenesis
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GO:1901227
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negative regulation of transcription from RNA polymerase II promoter involved in heart development
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GO:1901228
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positive regulation of transcription from RNA polymerase II promoter involved in heart development
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GO:2000138
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positive regulation of cell proliferation involved in heart morphogenesis
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Cellular Component |
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PDB ID |
MGI:106095
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InterPro |
IPR002715
Nascent polypeptide-associated complex NAC domain
IPR009060
UBA-like
IPR016641
Nascent polypeptide-associated complex subunit alpha
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PFAM |
PF01849
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PRINTS |
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PIRSF |
PIRSF015901
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q60817
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PhosphoSite |
PhosphoSite-Q60817
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
17938
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UniGene |
Mm.3746
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RefSeq |
NP_038636
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MGI ID |
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MGI Symbol |
Naca
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OMIM |
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CCDS |
CCDS24258
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HPRD |
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IMGT |
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EMBL |
AK146197
AK151928
AK161678
AK168023
AK168169
AK168607
AK169432
AK169435
BC029830
BC083340
BC099375
U22151
U48363
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GenPept |
AAB18733
AAB80961
AAH29830
AAH83340
AAH99375
BAE26971
BAE30804
BAE36526
BAE40008
BAE40130
BAE40474
BAE41173
BAE41176
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