InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nop10

Summary

InnateDB Protein

IDBP-196475.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nop10

Protein Name

NOP10 ribonucleoprotein homolog (yeast)

Synonyms

1110036B12Rik; Nola3; NOP10P;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028553

InnateDB Gene

IDBG-196473 (Nop10)

Protein Structure

UniProt Annotation

Function

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Note=Also localized to Cajal bodies (coiled bodies). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0030515	snoRNA binding

Biological Process

GO:0001522	pseudouridine synthesis
GO:0006364	rRNA processing
GO:0008150	biological_process
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005575	cellular_component
GO:0005730	nucleolus
GO:0015030	Cajal body
GO:0072588	box H/ACA RNP complex

Protein Structure and Domains

PDB ID

MGI:1913431

InterPro

IPR007264 H/ACA ribonucleoprotein complex, subunit Nop10

PFAM

PF04135

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CQS2

PhosphoSite

PhosphoSite-Q9CQS2

TrEMBL

UniProt Splice Variant

Entrez Gene

66181

UniGene

Mm.401210

RefSeq

NP_079679

MGI ID

MGI Symbol

Nop10

OMIM

CCDS

CCDS38198

HPRD

IMGT

EMBL

AK004120 AK012875 BC028497

GenPept

AAH28497 BAB23180 BAB28529