InnateDB Protein
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IDBP-196689.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eif4e
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Protein Name
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eukaryotic translation initiation factor 4E
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Synonyms
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EG668879; eIF-4E; Eif4e-ps; If4e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000029803
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InnateDB Gene
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IDBG-196687 (Eif4e)
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Protein Structure
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Function |
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage- specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. {ECO:0000250, ECO:0000269PubMed:18805096}.
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Subcellular Localization |
Cytoplasm, P-body {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:22900038}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
29
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
45 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:95305
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InterPro |
IPR001040
Translation Initiation factor eIF- 4e
IPR023398
Translation Initiation factor eIF- 4e-like domain
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PFAM |
PF01652
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P63073
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PhosphoSite |
PhosphoSite-P63073
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TrEMBL |
Q3TK95
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UniProt Splice Variant |
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Entrez Gene |
13684
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UniGene |
Mm.470781
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RefSeq |
NP_031943
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MGI ID |
1L8B
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MGI Symbol |
Eif4e
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OMIM |
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CCDS |
CCDS38654
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HPRD |
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IMGT |
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EMBL |
AK167097
BC010759
BC085087
M61731
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GenPept |
AAA37545
AAH10759
AAH85087
BAE39250
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