InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Runx3

Summary

InnateDB Protein

IDBP-196775.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Runx3

Protein Name

runt related transcription factor 3

Synonyms

AML2; Cbfa3; Pebp2a3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050353

InnateDB Gene

IDBG-196773 (Runx3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	2 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0002062	chondrocyte differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007411	axon guidance
GO:0031069	hair follicle morphogenesis
GO:0031175	neuron projection development
GO:0032609	interferon-gamma production
GO:0048469	cell maturation
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:102672

InterPro

IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
IPR008967 p53-like transcription factor, DNA-binding
IPR013524 Runt domain
IPR013711 Runx, C-terminal domain
IPR016554 Runt-related transcription factor RUNX

PFAM

PF00853
PF08504

PRINTS

PR00967

PIRSF

PIRSF009374

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt