InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mip

Summary

InnateDB Protein

IDBP-196887.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mip

Protein Name

major intrinsic protein of eye lens fiber

Synonyms

Aqp0; Cat; Hfi; Lop; MIP26; shrivelled; Svl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026455

InnateDB Gene

IDBG-196885 (Mip)

Protein Structure

UniProt Annotation

Function

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Disease Associations

Note=Defects in Mip are a cause of autosomal dominant cataract. The cataract Fraser mutation (Cat-Fr or Shrivelled) is a transposon-induced splicing error that substitutes a long terminal repeat sequence for the C-terminus of Mip. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of Mip to the cell-membrane.

Tissue Specificity

Major component of lens fiber gap junctions.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005212	structural constituent of eye lens
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015250	water channel activity
GO:0015267	channel activity

Biological Process

GO:0002088	lens development in camera-type eye
GO:0006810	transport
GO:0006833	water transport
GO:0007154	cell communication
GO:0007601	visual perception
GO:0015722	canalicular bile acid transport
GO:0050896	response to stimulus
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005921	gap junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0046691	intracellular canaliculus