InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDM4B

Summary

InnateDB Protein

IDBP-19713.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM4B

Protein Name

lysine (K)-specific demethylase 4B

Synonyms

JMJD2B; TDRD14B;

Species

Homo sapiens

Ensembl Protein

ENSP00000159111

InnateDB Gene

IDBG-19711 (KDM4B)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269PubMed:16603238}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00537, ECO:0000269PubMed:15927959}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005925	focal adhesion
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR002999 Tudor domain
IPR003347 JmjC domain
IPR003349 Transcription factor jumonji, JmjN
IPR011011 Zinc finger, FYVE/PHD-type

PFAM

PF00567
PF02373
PF08007
PF02375

PRINTS

PIRSF

SMART

SM00249
SM00333
SM00558
SM00545

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O94953