InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arnt2

Summary

InnateDB Protein

IDBP-197323.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arnt2

Protein Name

aryl hydrocarbon receptor nuclear translocator 2

Synonyms

bHLHe1; Hif-2b; mKIAA0307;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082154

InnateDB Gene

IDBG-197321 (Arnt2)

Protein Structure

UniProt Annotation

Function

Specifically recognizes the xenobiotic response element (XRE).

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Restricted to adult brain and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0017162	aryl hydrocarbon receptor binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007417	central nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0009410	response to xenobiotic stimulus
GO:0009636	response to toxic substance
GO:0032355	response to estradiol
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:107188

InterPro

IPR000014 PAS domain
IPR001067 Nuclear translocator
IPR001610 PAC motif
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold

PFAM

PF13188
PF13426
PF00010
PF08447
PF00989

PRINTS

PR00785

PIRSF

SMART

SM00091
SM00086
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt