Version 5.4
Mus musculus Protein: Lclat1
Summary
InnateDB Protein IDBP-197344.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lclat1
Protein Name lysocardiolipin acyltransferase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000068690
InnateDB Gene IDBG-197342 (Lclat1)
Protein Structure
UniProt Annotation
Function Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages. {ECO:0000269PubMed:15152008, ECO:0000269PubMed:17675553}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:15152008}; Multi-pass membrane protein {ECO:0000269PubMed:15152008}.
Disease Associations
Tissue Specificity Widely expressed with highest expression in heart, liver and E12.5 aorta-gonad-mesonephros and lower levels in the E16 fetal liver and adult bone marrow. In bone marrow, highest levels are found in B-cells compared with whole bone marrow, T- cells, erythrocytes, and granulocytes. {ECO:0000269PubMed:15152008, ECO:0000269PubMed:16620771, ECO:0000269PubMed:17675553}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0007275 multicellular organismal development
GO:0008152 metabolic process
GO:0016024 CDP-diacylglycerol biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2684937
InterPro IPR002123 Phospholipid/glycerol acyltransferase
PFAM PF01553
PRINTS
PIRSF
SMART SM00563
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UN02
PhosphoSite PhosphoSite-Q3UN02
TrEMBL B0V2Q9
UniProt Splice Variant
Entrez Gene 225010
UniGene Mm.329194
RefSeq NP_001171439
MGI ID
MGI Symbol Lclat1
OMIM
CCDS CCDS37689
HPRD
IMGT
EMBL AC112949 AK144580 BC147499 BC150884 BC158076 BC158079 CH466537 CT025726
GenPept AAI47500 AAI50885 AAI58077 AAI58080 BAE25946 EDL38407

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca