Version 5.4
Homo sapiens Protein: LARP6
Summary
InnateDB Protein IDBP-19744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LARP6
Protein Name La ribonucleoprotein domain family, member 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000343869
InnateDB Gene IDBG-19740 (LARP6)
Protein Structure
UniProt Annotation
Function Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269PubMed:20603131, ECO:0000269PubMed:21746880, ECO:0000269PubMed:22190748}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17383118}. Nucleus {ECO:0000269PubMed:17383118}. Note=Shuttles between the nucleus and the cytoplasm.
Disease Associations
Tissue Specificity Expressed in numerous tissues. {ECO:0000269PubMed:17383118}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003723 RNA binding
Biological Process
GO:0006396 RNA processing
GO:0006417 regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BRS8
PhosphoSite PhosphoSite-Q9BRS8
TrEMBL
UniProt Splice Variant
Entrez Gene 55323
UniGene Hs.604446
RefSeq NP_932062
HUGO HGNC:24012
OMIM 611300
CCDS CCDS10236
HPRD 10966
IMGT
EMBL AC009269 AC090868 AF443828 AF443829 AK002058 AL833876 BC006082 BC009446 BC014018 BC039153
GenPept AAH06082 AAH09446 AAH14018 AAH39153 AAN76710 AAN76711 BAA92061 CAD38733

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca